Anti-melanogenic activity of phytosphingosine via the modulation of the microphthalmia-associated transcription factor signaling pathway

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Anti-melanogenic activity of phytosphingosine via the modulation of the microphthalmia-associated transcription factor signaling pathway.

BACKGROUND Microphthalmia-associated transcription factor (MITF) suppresses the expression of enzymes controlling the production of melanin. Phytosphingosine is a well-known cosmetic agent, but its anti-melanogenic activity and mechanism of action remain unclear. OBJECTIVE This study was designed to investigate the effects of phytosphingosine on melanin synthesis and elucidate the plausible m...

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ژورنال

عنوان ژورنال: Journal of Dermatological Science

سال: 2017

ISSN: 0923-1811

DOI: 10.1016/j.jdermsci.2017.03.011